I'm no expert compared to many here on this type hunt, I do one big hunt each year instead of multiple ones, plus hunt my home state of Kansas.
I will be hunting CO 2nd season deer this year again. I just got back from a scouting trip to the new unit we will be hunting and will have a gear list built on Excel within the next couple weeks after seeing the country. I'd be happy to email it to you if you PM me an address. I have been rifle hunting the West in October and November since 2008. I have 3 trips to Alaska since then as well and ranch for a living. I've learned a few things about staying safe and comfortable outdoors.
I'll add that I have never been able to pre-scout enough to be after a specific buck on opening day of a muley hunt. I always do a 3-5 day scouting trip, but I have not located a giant buck during those trips. I tend to do a lot of driving the UTV and learning access, glassing points, and eliminating parts of the unit. I run all daylight hours and try to see as much country as possible rather than trying to locate a target buck. My E scouting is much more productive after I've been in the unit for a few days. If I lived closer and/or didn't have cattle to feed every morning, I'd change that strategy.
I have a few rules for hunts I drive to I'll add here. Many of them have been said already, and I learned several from people here in the first place.
I always take gear for a truck hunt and a backpack hunt. I keep the backpacking gear separate from the truck camp gear. I like having both options, and I like the backpacking gear to be ready to go at a moments notice, not set up at a base camp.
I always have an emergency kit with me. It always includes a good fixed blade knife, tarp or poncho, a 2 person space blanket, a metal container to melt snow or boil water, puffy layers, and multiple ways to start fire. I have more stuff but some of it changes between hunts. These do not. I make these multi-use items too, not just a survival kit. The UTV usually has my backpacking gear in a dry bag in it if I'm not using it. That way I have a camp kit in there separate from my day hunt gear in my pack. Base camp gear is at generally at the truck. I like having options and redundancy as long as I'm not carrying it on my back.
An InReach is a great item to have, as is OnX with your vehicle, camp. etc marked.
I always plan an exit strategy. I want my truck and utv trailer to be somewhere I have a good chance of getting out of in bad weather. If that means I drive the Ranger further and camp from it, backpack, or truck camp and drive more/sleep less, I do what's needed.
Make sure you go into the back country with plenty of fuel for anything that needs it.
Take the tools you need as far as you can without carrying them on your back. Shovel, saw, axe, 12V air compressor, tire chains, tire plug kit, spare serpentine belt for the truck & drive belt for the UTV, spare tires for everything, chains, tow ropes, etc. I probably go overboard because I have all this stuff for the ranch, but I like options here too. I want my vehicles as self-sufficient as possible.
There are a lot more things I could add, but those have been factors in making sure all my adventures so far have had safe endings.