I went nosler over the .223 because of the speed. It’s much faster out of the same length barrel, and I should be getting some really good speed out of the hand loads my buddy is making. 22-250 would be good also, I just don’t see the ammo around here very often. My buddy reloads for me but I don’t want to bank on that and .22 nosler being such a boutique caliber made me realize why I should have went with something more readily available. 22-250 is probably a better choice than a .243 for coyotes, but I know a bunch of guys running the .243 and it’s very proven around here.