KHntr
WKR
Depends on your bullet. If you are tossing a 212 ELDm, then more tissue damage for sure and a bigger margin. If you are throwing a 180 TSX, then less tissue damage and less room for shot placement error.However, none of this covers a margin of error, a shanked shot or misjudge distance. To me a margin of error speaks to a shot placed in an unintentional location. If I screw up with my .300WM and dump one in the leg or guts, whats that .300wm got in terms of margin of error over the little .223?