For me, the Exo 3500 has been perfect for day hunts to 7 day pack-ins. On the 7 day, the bag was definitely packed to the brim so on a 10 day I could see maybe wishing for a bigger bag, but I never get to go out for that long- usually just 2-3 days. After getting my elk down I took 70# of meat and all my gear out in the first load.
Honestly, using the load shelf in this way was perfect for me. I liked that the meat could breath and was high and tight to my back and I didn't have to worry about keeping blood off of my gear. For the second load I went back and put 85# ponds of meat directly in the bag with just some essential items in the lid and back stretchy pocket. This is the only picture I have of how that looked.
To me this worked exactly how I had planned and hoped I couldn't really imagine wanting a bigger bag. I think if I was trying to get everything out in one trip, the load shelf could easily swallow 100# and then still have camp in the bag. I would never be able to carry more weight than that so a bigger bag wouldn't help. This is my opinion, but of course I'm still learning.