The drawback is you can’t be as precise with your zero at 200 as you can at 100. And if you are going to dial for longer range, that matters.I have a 6.8 Western Xbolt as well. I zero mine @ 100 yards now, but I'm considering bumping it back to 200 for hunting. I don't see any real drawbacks.
It would have me 2.7" high @ 100 yards and 7.6" low @ 300 yards. Seems like a good compromise for fast shots out to 300 yards with hand loaded 170 EOL @ 2950fps.
With 145 ELD-X @ 3135fps it's even better, 2.3" high @ 100 yards and 6.8" low @ 300 yards.
Ultimately it's whatever you're more comfortable with