Hunting in the woods, we shoot deer at under 50 yards usually. My last two, my son's first this year, and my hunting buddy's deer this year were all neck shots. All bang-flop. Two with 45/70, one 30-30 and my son's was 6.5 Grendel.
My son had no other shot, and had a steady rest and time to get set. His was 48 yards, and his rifle was zero'd at 50, so why not? The rest were 20ish or less.
I've shot a lot of cows in the neck on meat hunts, just to limit meat damage. I hate blood-shot all around the shoulders. All the ones I've taken worked well.
Under 100 yards for me I’ll take the neck shot to avoid meat damage. Every animal I’ve seen take a neck shot dies instantly, this is a small sample size though and only used it and seen it on deer.