I like the 7mm Remington Mag but there is nothing wrong with a 308.
A Rem 700 in .270 Win, shooting 110gr Barnes TTSX hand loads, has been a very accurate and effective combo for me so far on mule deer. Having said that, I have a new Kimber Subalpine in .280 AI that I am really liking, and looking forward to using on my next hunt.
What velocities are you getting with that 110?
Ok, I just checked my load data. I noted the muzzle velocity at 3150, so I suspect that was an average. I use 56.0 gr of H4350 which is actually the minimum listed in the Barnes manual for that bullet, but it was what grouped the best. I'll take accuracy over velocity any day. I use Win brass and WLR primers. Shooting for .050 off the lands, I ended up with OAL 3.456 (no, I am not making that up )
The load performs well enough that I have never been tempted to fiddle with it.