I started with 168gr tsx from my 300 win mag, then moved to 168 ttsx. Also 180 gr ttsx out of my .358 win. Never caught any of them in a deer, and usually had a decent blood trail, just very un-impressive wounds, unless bone was hit, and deer always ran 100-200 yards, sometimes more, with non cns hits.
Been shooting 80gr eldx out of my 22-250 the last 2 deer seasons, and have had 3 out of the 5 deer killed with it have (what's left of) the heart loose and falling out of the chest cavity when gutting. Never had that happen with any of the bigger rounds I've used. The furthest one ran was 100 yards, most less than 30. Had decent blood trails with all, although only needed it on the 1 that ran 100 yards. The other 4 never made it out of sight .