Also i think a 325gr 45cal bullet is not really comparable to a 223 or 243 bullet at similar fpe. The accuracy of these guns is also amazing. 1/2 moa is not out of the norm. It's really just a rifle. The only thing in common that it has with a standard muzzleloader is that it's loaded from the muzzle.
Agreed. The comparison I made was strictly in reference to those rounds' kinetic energy. And, if a ~300 grain round has low enough KE that it's comparable to a .22... you're probably not getting the kind of expansion necessary to make ethical kills.