We shoot til down! Deer are usually one-shot, cause they either drop or run off. Bigger critters usually get a follow-up if they're still up and we have a shot. I've heard too many stories of animals dropping and then getting up, never to be seen again.
Son's muzzy bull elk, he dropped him at 60yds, had his head up still, so he put second in.
Daughters first oryx, dropped after first 140yd shot from 300wm, having heard the stories, we put two more in just to be sure. Her second oryx, 60yds 6.5cm, DRT, one more from 60 plus another once we got up to it just to be sure.
Cow elk 300wm, 100yds, I put two perfect in the vitals, and would have kept shooting, but she was hunched up and blood was pouring, so I held off anymore.
First archery elk, 4 arrows shot, 2 through vitals, not sure where the other 2 ended up.