One moose with a 200gr ELD-X out of my .300wm at 150 yards. My MV with this round is 2848fps. The bullet clipped a little bit of front shoulder and took out both lungs. Slight quarter towards shot. Moose dropped basically in it's tracks.
I've killed a dozen or so smaller critters (sheep, deer, pigs, etc.) with the 143gr ELD-X coming out my a 6.5cm at 2629fps at ranges from 90-350 yards and all were pass through shots in the boiler room.
I have yet to recover any of the ELD-X bullets to check them out, but I would like to based on what people described as sub-optimal frangibility.
I will say that they make things dead really quickly, which is usually what I am after. They do make a mess when they hit bone and cause more meat damage than say copper mono bullets.
Based on my experience, I wouldn't hesitate to use them on any game animal. Based on the experience of others, I'd be a little worried about using them if targeting brown bears specifically where you'd want something that stays together better, in my opinion at least.