Yes. Post 2018, they went to a pickup-specific engine architecture. Details are all over the internet. The 68RFE transmission sucks. Aisin is an excellent transmission. 2016 to 2018 6.7 is the best diesel engine ever put in a pickup truck - now let me go find some cover to duck all the flak I'm about to get.
Jury is still out. Engine was re-designed again for 2025. They have the 8 speed transmission which is a vast improvement over both the RFE and Aisin. Probably the best transmission on the market right now. The engine shares a lot of the features that made the 2019 to 2024 engines suck, with the addition of a modified CP4 fuel system. Why makers just absolutely insist on using that stuff I can't understand. It's supposedly upgraded and has a different name, but it sure looks a lot like a CP4 to me. The 25's have glow plugs instead of a grid heater so this bolt thing goes away. Broken off glow plugs are just as bad. We shall see. Me personally, I'd wait a couple more years and see or if you need to buy now, Chevy probably has the most dependable diesel driveline right now. Ford's is also pretty excellent and the power is absolutely stupid.