I have a couple of friends in that area. One guides for elk & muley (Mule Creek Outfitters) & he got zapped by a grizzly, 4 years ago on Beaver Ridge. Nothing major, just a few stitches & a couple of days in hospital plus a serious WGF investigation.
My other friend has lived in the area for 60+ years. He tells me that they're getting more prevalent, but has still only actually seen 4 or 5 in his lifetime.
There were a couple of hiker/bear interfaces last year just outside Pinedale, at the bottom end of the Wind River range.
I'd be aware, but probably not paranoid about it. I know I'm taking my pistol this year, just in case, but I'm not expecting to see any bears.