Progressive presses and tinkering go hand in hand. You may get lucky, but chances are that at least some tinkering, adjusting, tuning will be required.
Also depends on what your reloading and how much volume.
In general dillon is considered the standard by most. Especially pistol reloaders.
Personally, they work fine, but sit in a weird price spot to me with the success of the new Lee. Expensive but a safe bet. However, still have quirks like all progressives.
Ive never used the hornady lock and load. But im sure it works.
I have the lee pro 6000, I think its fantastic. Much better then the older lee models.
Haven't messed with the 10 stage presses.