I hunt both ways. If it's a unit/area I know well and am confident holds elk, I'll happily backpack in for a few days. On the other hand, if its a new area or an area in which I know the animals are highly mobile, I'll find a place to camp next to the truck so I can be mobile day to day as needed. Last year I did a hunt in CO with camp on my back and 2 hunts in MT truck camping. As I get older, I find that the ability to have a whole lot of comforts at the end of a very long day and the ability to be mobile searching for animals makes for a very pleasant hunt. Don't get me wrong, sleep equipment and dehydrated food have come a long way...but they ain't a cot and 2 ribeyes in the cooler.
I would be curious to hear about your friend's/acquaintance's morning and evening routine that makes base-camping untenable. Generally I'm up well before dawn and heading to a location picked out the night before rather than glassing from roads or taking a stroll a half-mile from camp. I don't use horses or ATVs...up early, stay late, go like hell. We still kill stuff.
I would echo others' feedback on your planned trip...if this is your first go, plan to basecamp at a road accessible camping spot. If the spirit moves you, do an overnight. Find a way to hunt that you enjoy, and get after it.