Low chest, just behind the heart so it still pumps, you will have blood spraying everywhere!
A bull elk that I shot low chest, just behind the shoulder with a 168 gr TSX bullet from my .300 Wby only made 3 jumps and sprayed blood 10' out on the fresh snow from both sides.
The lower arrow in this picture shows the .30 calliber entrance hole in the hide and the top arrow shows the beginning of the expanded hole in his chest.
The upper arrow in this pic shows the expanded TSX bullet exit hole from the chest, and the lower arrow points to the 1" or so bullet exit hole through his skin on his off side.
For about 20 years my elk rifle was my .30 Gibbs shooting 180 gr Nosler Partition bullets. I've rarely spent a lot of time looking for the bullets in the animals that I shot, but here are 180 gr Partitions that were just under the skin of the off side of 6 of those bulls.
As designed, the front half of the bullets quickly opened to quickly transfer the bullet's energy into the animals, and the intact back half pushed the bullet deep through the animal's body, but the large flat front area of the remaining bullet didn't have enough energy to go through the skin.
On one of my African hunts I used my 7mm RM shooting 160 gr Accubonds. One of my PH's, who also handloaded his 7mm RM, was continually impressed with the large internal wound channels that my Accubond bullets made in the animals that I shot.