He talks about .45 loads in the podcast (not .50). So, not really applicable to .50. He mentions at the end that N130 will be a good powder for the .50s but gives no details.Try this podcast: https://podcasts.apple.com/us/podcast/northwoods-whitetails-podcast/id1729405201?i=1000670630649
A lot of the stuff around bc’s and some other stuff he says make me think he’s relaying info and doesnt really understand the nuances firsthand, but seems like a good place to start as it squarely answers your questions. If diff bullet or something Id call.