There are different ways to look at this. Some units are so popular because of terrain and ease of the hunt, others are popular for inches of horn, some are popular for the amount of elk you see. What is your priority?
How do you feel about hunting in Grizzly country?
Since your talking preference points I will assume your a NR. To that end, Wyoming takes 10% of the total licenses and sets those aside for NR. From that the preference points are used. So if there are 100 licenses, 10 are available to NR. Preference points help in the draw and as a resident I truly wish we got them. Based on what your looking for I would start with the harvest odds and then figure out where the best odds are. If you are okay with having a guide you can look at wilderness areas. Some areas have wilderness within them but not encompassing the whole area. For example up by Cody and in area 100. The rough terrain is in the majority of the northern and western part of the state with some fairly rough stuff seen in the south central. What class of bull are you looking for? What Defines good chance? Anymore I look at 50% success as a good unit with the chance at a 350 bull being amazing. Not saying there are not bigger Bulls.
Okay that definitely opens up areas. It is possible to find "huge" bulls but not every area holds them. How many years from now are you looking at doing the hunt or are you looking at next year?
WY allocates 16% for NR, with NR landowners drawing first. The remaining are reallocated special/regular and points/random.