Will a 7PRC kill a brown bear? Yes. If you're tracking a wounded brown bear are you going to wish you you had a .375H&H instead? I definitely would be. I've seen brown bears killed with .280 ackleys, 30-06s, 7mms, and all the regular big boys. Even with 375s you can't count on one shot kills, and hardly ever with anything smaller. If you use your 7PRC would not recommend shooting over 250yards (with any caliber) and be sure the bear is in a spot where you'll get good follow up shots. The rule of thumb with killing brown bears is shoot till they're done moving, holes in hides are easier to patch than holes in yourself. It's not a meat hunt.