I moved to .350 Legend here in lower MI shortly after it came out. I use a Winchester XPR with Winchester 160 gr power max bonded, and my son uses a CVA Scout with the Winchester 150 gr. XP. Between us, we've taken 5 deer with the .350.
The longest was 115 yards with the 150 XPs. The buck was quartering toward us when shot. He kicked at the shot and ran 20 yards where he nosed in the dirt. We watched him lay there motionless for a few minutes before we walked out to find him dead. We looked for blood out of curiousity and couldn't find any. We had a hard time finding the entrance hole and there wasn't an exit hole. When we processed him we found the bullet had hit the heart, passed through a lung, and lodged in the rib cage. That would explain the quick death and no blood trail.
I've had a pass through with the 160 gr loads, but the 150s have consistently lodged in the opposite side. Luckily none have run more than 75 yards, with most dropping within sight after being hit. I chalk that up to practice and intentional bullet placement rather than just terminal performance.
We could never get the 180 grain loads to shoot worth a darn in either rifle. As others have said, stick with the lighter stuff.