Using typical standard hunting bullets and ammo, a 300 win mag and 180's will have more energy than a 338 and 225's at around 400 yards. I love my 338 winny and if you shoot it accurately why not take it. I've found my 338 shooting 200 & 225's producing less damage than my 300 win mag and 180's just due to velocity at impact on the elk I've killed. Shoot them through the ribs no problem. Hit a deer in a shoulder with any high velocity round and you're going 'blow' it up. Guys shooting these heavy caliber high BC .30 cal bullets out of 300 win, 300 PRC, 30 Nos. are easily exceeding 338 win mag energy. Pick your shots if you can, keep it in the ribs.