Once upon a time I got a wild hair to kill a deer with an old Marlin 30-30 I used to have, with a peep sight.
First time I took it hunting, right at dark I had a doe come out and I could see her clear as day through my binocular but couldn't make a shot with the peep sight and fiber optic bead.
Thus concluded my interest in hunting dark things with open sights.
I love the idea of AI cartridges and owna .280AI now and had a .220SwiftAI in the past and see the best trends in modern cartridges (such as the 6.5cm, etc) as being descended from what Ackley did decades ago.
But a peep-sighted rifle has limits on both range and lighting conditions and improving its ballistics doesn't fix that. I'd pass. But if I were younger with better eyes, I can see doing it differently. If you have a 200-yard set of eyeballs, go for it.