My Moose died from a 6.5 accubond. Anything through the lungs will kill any animal.
A lousy shot from a 300 win mag is still a lousy shot. and the Moose ain't dieing so quick.
My key, is too keep it off the shoulder, and go for the lungs.
There is a white tail guide up in Maine that doesn't allow .243, 6.5, 7mm-08, or .260. It's an old timer guy that can certainly put you on a deer, but he's old school, and can't comprehend how destructive a .243 is.
All the muzzle brake guys. You bugger your shots, because you know how deafening it is.
me, I can sit at the range for hours with my little short track & practice for hours.