I think your intended use and range limits set the stage. What is your intended use, it is said that under 400 yds dont worry about variation in velocity drop. John Barsness has some articles about temps as it relates to POI, Velocity and Accuracy variation. I suggest you read them if you can. I opted to only develop only in like or similar conditions I will be hunting in. No easy answer here, just time and experiments to get where you want to go.