Mine is a 30-06, and I had tried several factory loads, and a couple different bullets previously, and nothing shot even acceptable groups. I started hand loading and was using H4350 with 178 gr ELD-m bullets, in lapua brass. I always heard H4350 was the gold standard for 160-180 grain bullets in the 30-06, so I did not try any other powders. After extensive load testing and seating depth testing, I was able to get about .6-.7" groups with the seat depth around 0.060 off the lands. That was best in a couple different tests I did, so I thought it was the load for me... until I kept using it and the groups became as bad as everything else. Running all of my actual numbers through GRT I discovered that I was not likely getting complete burnt powder, and I have read that having less than 100% burn could potentially lead to inconsistency... since inconsistency is exactly what I was seeing, It lead me down this rabbit hole of how to find more optimal powders. I have seen several reloader articles and videos that will only consider powders that get 100% burn.
Now I have ordered a new barrel for it, and decided to switch it to a 280 AI, just to get a little better wind management with a slightly faster bullet with a better BC.... that and I just have always wanted a 280 AI... I already have accumulated some Peterson Brass (supposed to be the highest quality brass made in 280 AI), a good pile of Berger Classic hunter bullets (so they should be very consistent and forgiving), and both CCI & Federal primers (I'll test those after finding the best powder). So my components are good enough to avoid blaming them. Now I really just need to find the right powder. I am willing to test enough to find the one that works best, I just don't want to waste time on ones that are unlikely to give good performance, and I would like to narrow it down to what look like the best options first. Right now I have found the Range of powders to run from H4350 on the fast end, to H4831 and N560 on the slower end. H4350 would likely only give me around 86-87% case fill, but would burn 100%. H4831 I would have to compress to around 103-104% case fill to get to the right pressure range, however it would only get around 90% burnt powder... Between those two extreems, there are some options that look good, like N555, N160, Ramshot Hunter, IMR 4831, and AA4350. I've seen alot of people get great results with N560, but it will be around 95% burnt powder... which brings me back to the original question... does that matter? and if it does, at what point does it matter? Every powder I have listed is worth a try, plus probably a few others, but it would cost me an arm and a leg just to test them all. I am planning to test H4831sc first, only because that is the only one I have on hand. I am trying to figure out which powder I would test next if the H4831 is not giving the results I can live with.