as far as the kuiu stuff goes the guide pants are what you are looking for. soft shell, fleece lined, dwr and wind resistant but too bad they don't come in solids right now. Attack pants are very comfy with all of the above minus the fleece lining. Having said that they can withstand moderately...
I regularly run 8-15 miles for training, my longest run being 25 miles and 6,000 foot elevation gain. I love trail running and getting out in the mountains. I have had weeks that I have run 70-80 miles. I have found that my body feels better with minimalist shoes than with thick padded running...