WY hunting is nothing like eastern hunting. The preference point thing is real. WY has diff units and general areas. Mtns and rolling plains. Sage and brush and grasslands and deserts.
The WY website has everything you need. The harvest & draw & pref points data is all available in excell spreadsheet. You might want to start there and see what the trends are - BUT-BUT - next year is the first year the special points are worth 3 or 4x the original prices, so the draw game will change some.
Anyway, once you identify the tags you can get (preference point info), then you can decide if you want to hunt mtns or prairie or grasslands or mix. You can't hunt national forest without a guide.
Most areas with higher success rates will have mostly smaller bucks. You can also check on the various deer diseases CWD and such.
Definitely consider the doe hunt - it will be the same amount of energy and expenses, just can't shoot the buck you will likely find. A lot of guys like it. I did it for antelope in 2017 and regretted it. Opening morning I was standing 20-30 yards from the biggest antelope buck we saw in 3 days and shot an antlerless one in front of him. Nope, never again.
If you want a 1 and done, guided will give you a dream hunt - no pressure, etc. It will cost a little more, but it will also be doable in a year or two vs unknown amount of time. We were chasing an antelope unit and after 4 yrs of point creep decided to go guided, went guided - the main diff is no other hunter pressure when you are the only guys on a 25,000-50,000 acre ranch.