Kifaru's new use of Dimension Polyant fabric ("Xpac") has gotten a lot of attention, and a fair few of the answers to various questions and chatter generally has been misleading. I'll try to be as brief as possible in the following.
"Waterproof" fabrics
I'm not aware of anyone who uses a nonwaterproof fabric for the body of a backpack hunting pack. Kifaru is selling themselves short by claiming their new Xpac bags will be actually waterproof. Traditional pack fabrics are made waterproof by coating one side with polyurethane. Xpac is made waterproof by laminating a plastic film to one side. The Xpac laminate is (broadly speaking) heavier, more waterproof (200 psi), and more expensive than polyurethane coating. It is also more rigid/crinkly. The problem with the waterproof question is that the amount of PU applied to fabrics like Cordura varies widely. I've seen quality stuff (like that featured in every Kifaru product I've seen) with a thick glossy layer, and cheapo stuff with barely any at all. All of it is waterproof by one definition. The Cordura side pockets on the pack I took skiing today filling up with snow in the blizzard and when I emptied it 15 minutes ago were full of 2 inches of standing water, which was not leaking through the fabric.
What does become relevant is the PSI rating of that PU layer. I've had quality Cordura leak when it was on the bow of my packraft getting blasted by waves, when the pack was covered in wet snow for hours, and when a bloody bag of meat was sitting against, again for many hours. There is a case to be made that for many applications Cordura is often not waterproof enough, but it is waterproof, and saying otherwise is not really accurate by any meaningful standard. Plenty of people do not need the extra waterproofedness provided by Xpac, and for them they aren't getting much if anything by buying it.
Stone Glacier's use of Xpac is illustrative here.
It is sort of worth mentioning that in theory Xpac is more durable as a treatment than PU, insofar as PU eventually flakes off the fabric due to UV and abrasion. Quality PU takes a long time to do this, and Xpac hasn't been in wide use long enough to really provide a good test. (I've never heard of a confirmed case of XPac delaminating, and have made a few packs to really try to get it to fail in this way, but still.)
It is also worth mentioning that over the long term I've never owned a truly waterproof pack. Putting aside the whole stitching issue, long term use and abrasion will eventually put a bunch of tiny holes in your pack. Dig out an old bag which has seen good service, fill it with water, and see what happens. Kifaru is smart to use Cordura as an extra outer layer on the bottom and low sides of their Xpac bags, but in really wet conditions I would still put things like insulation and electronics in some kind of dry sack.
Face fabric is face fabric
Xpac is not a fabric, really, it is a laminate. If you have enough money Dimension Polyant will laminate whatever fabric you care to send them. You can get 500D Cordura Xpac, or the 210D Kifaru appears to be using, or a lunch of other stuff. Face fabrics perform the same no matter the waterproofing layer. In theory the XPac laminate increases tear and puncture strength, but in 200+D fabrics this is a moot point. For those who used it, the old Kuiu 160D Ultra pack fabric is a fair equivalent of VX21 when it comes to abrasion, i.e. it isn't that great.
It follows that face fabrics retain water the same, whatever laminate is underneath. All pack fabrics I can think of come treated with a DWR (same as your rain gear) and just like with your rain gear that DWR wears off very fast when exposed to dirt. In my experience new and unabraded pack fabrics don't retain too much water, and older fuzzed out fabrics retain plenty. I'd be all for a fabric with some sort of permanent external coating, but Arc'teryx is the only company I can think of who has done this (with PU). IMO water weight retention has much more to do with the foams and fabrics used on the harness elements of a pack than the main fabric or coating on it.
Ignore the following if your attention is waning
Xpac nomenclature is pretty simple. The number denotes the denier of the face fabric. X fabrics have the characteristic X/Diamond grid, between the face fabric and laminate. V fabrics have a white layer of fabric on the inside of the laminate.
I've always found the 2 Cordura face fabrics to perform best. X33 (330D Cordura) is widely available in multicam, and X50 (500D) in black multicam. The V fabric in the laminate makes the interior of dark colors easier to see inside, and otherwise doesn't seem to add anything. You need a headlamp to see to the bottom of a big bag made of X50. The X laminate is a liability, something I can say definitively now that I've had some plain 33 Xpac for the past few weeks. The X fibers create abrasion points. They also provide some branding for Dimension Polyant , but hopefully D-P will let that go as they get more market share.
"Waterproof" fabrics
I'm not aware of anyone who uses a nonwaterproof fabric for the body of a backpack hunting pack. Kifaru is selling themselves short by claiming their new Xpac bags will be actually waterproof. Traditional pack fabrics are made waterproof by coating one side with polyurethane. Xpac is made waterproof by laminating a plastic film to one side. The Xpac laminate is (broadly speaking) heavier, more waterproof (200 psi), and more expensive than polyurethane coating. It is also more rigid/crinkly. The problem with the waterproof question is that the amount of PU applied to fabrics like Cordura varies widely. I've seen quality stuff (like that featured in every Kifaru product I've seen) with a thick glossy layer, and cheapo stuff with barely any at all. All of it is waterproof by one definition. The Cordura side pockets on the pack I took skiing today filling up with snow in the blizzard and when I emptied it 15 minutes ago were full of 2 inches of standing water, which was not leaking through the fabric.
What does become relevant is the PSI rating of that PU layer. I've had quality Cordura leak when it was on the bow of my packraft getting blasted by waves, when the pack was covered in wet snow for hours, and when a bloody bag of meat was sitting against, again for many hours. There is a case to be made that for many applications Cordura is often not waterproof enough, but it is waterproof, and saying otherwise is not really accurate by any meaningful standard. Plenty of people do not need the extra waterproofedness provided by Xpac, and for them they aren't getting much if anything by buying it.
Stone Glacier's use of Xpac is illustrative here.
It is sort of worth mentioning that in theory Xpac is more durable as a treatment than PU, insofar as PU eventually flakes off the fabric due to UV and abrasion. Quality PU takes a long time to do this, and Xpac hasn't been in wide use long enough to really provide a good test. (I've never heard of a confirmed case of XPac delaminating, and have made a few packs to really try to get it to fail in this way, but still.)
It is also worth mentioning that over the long term I've never owned a truly waterproof pack. Putting aside the whole stitching issue, long term use and abrasion will eventually put a bunch of tiny holes in your pack. Dig out an old bag which has seen good service, fill it with water, and see what happens. Kifaru is smart to use Cordura as an extra outer layer on the bottom and low sides of their Xpac bags, but in really wet conditions I would still put things like insulation and electronics in some kind of dry sack.
Face fabric is face fabric
Xpac is not a fabric, really, it is a laminate. If you have enough money Dimension Polyant will laminate whatever fabric you care to send them. You can get 500D Cordura Xpac, or the 210D Kifaru appears to be using, or a lunch of other stuff. Face fabrics perform the same no matter the waterproofing layer. In theory the XPac laminate increases tear and puncture strength, but in 200+D fabrics this is a moot point. For those who used it, the old Kuiu 160D Ultra pack fabric is a fair equivalent of VX21 when it comes to abrasion, i.e. it isn't that great.
It follows that face fabrics retain water the same, whatever laminate is underneath. All pack fabrics I can think of come treated with a DWR (same as your rain gear) and just like with your rain gear that DWR wears off very fast when exposed to dirt. In my experience new and unabraded pack fabrics don't retain too much water, and older fuzzed out fabrics retain plenty. I'd be all for a fabric with some sort of permanent external coating, but Arc'teryx is the only company I can think of who has done this (with PU). IMO water weight retention has much more to do with the foams and fabrics used on the harness elements of a pack than the main fabric or coating on it.
Ignore the following if your attention is waning
Xpac nomenclature is pretty simple. The number denotes the denier of the face fabric. X fabrics have the characteristic X/Diamond grid, between the face fabric and laminate. V fabrics have a white layer of fabric on the inside of the laminate.
I've always found the 2 Cordura face fabrics to perform best. X33 (330D Cordura) is widely available in multicam, and X50 (500D) in black multicam. The V fabric in the laminate makes the interior of dark colors easier to see inside, and otherwise doesn't seem to add anything. You need a headlamp to see to the bottom of a big bag made of X50. The X laminate is a liability, something I can say definitively now that I've had some plain 33 Xpac for the past few weeks. The X fibers create abrasion points. They also provide some branding for Dimension Polyant , but hopefully D-P will let that go as they get more market share.