Definitely not ideal, but it might not make a difference depending on your accuracy goals. Bushings aren’t an exact fit, cut rifling groove depth isn’t always exactly the same depth, not every barrel is dialed in exactly, and so forth.
Once in a while pass around a photo of a very off center chamber that still shoots great.
Personally I’ve not been lucky and a top quality barrel installed by a big barrel maker with a chamber slightly off kilter, didn’t shoot better than the mediocre barrel it replaced.
I’d definitely shoot it - right away you’ll know if it has potential.