The Hornady 88s have a bit of bad reputation terminally whereas the 80s do not. I have no experience shooting either on game at this point, but refer you to other discussions about it.
There are diminishing returns with the heavier, 22 caliber bullets at longer ranges. Spotting impacts on steel for practice with the 108 and 115 and 6 mm is hard enough at the ranges where the added BC would begin to make big differences.
There is also a substantial difference in trace. That is one reason why many go to the magical 25 cal with the 134/5 class bullets. Balance of recoil and down range visibility in competition and still having more bullet on target.
There are 95 grain Sierra match King you could nose ring and run like the 115 DTACs. I have thought about that, but Tubbs “leased” the nose ring gadget and locked down control of it which discouraged me from looking more into it.
I don’t think you’ll ever see anything heavier than 95 grains in a 22 caliber bullet. Could be wrong though.
For practical hunting ranges, the 80 grain bullets are great choices and effective, say inside 400-500. Beyond that, I like the higher BC 6 mm out of the PRC or SAUM case like the 6 UM 30 or 40.