There is always the cancelled or delayed flight possibilities.
We booked with a nearly 4hr layover to account for a possible delay. If the flight was cancelled which would definitely suck, we would end up at our destination no later than if we had driven, for no more money than the cost of the drive.
We drove last year, 5k mile round trip. The drive wasn’t bad and I actually enjoyed it, with that being said we took way too much unnecessary gear and realized we couldn’t gotten by comfortably with a small enough amount of gear to fly out.