That means a large wound, which is best accomplished with a fragmenting bullet. If you want to lose less meat, you actually need a smaller fragmenting bullet, or a tougher bullet. Tougher bullets don't make larger wounds, just deeper ones.
Maybe this info will help you arrive at some consistent thinking, right now you are claiming to want two contradictory things:
This is going to be a barrage of questions. It will help to view me as a skeptic relative to the matter at hand. I am going to do some load development for my new 6mm Creed. I live in the southeast where shots are rarely taken at more than 100 yards. But, I fancy that I will take a trip out west one day to hunt antelope, so I am going to do my load development with an eye toward the possibility that I might shoot out to say (for the sake of discussion) 500 yards. This is a hunting gun.
Time to order bullets. I see questions asked frequently across various forums asking about using...