Not quite 22 Creed, but close enough:
I like to tinker and thought I'd try the 53 gr Vmax out of my 1:8 22-250 AI. Loaded a few to check pressure with RL-15 and took my can off in case RPMs were too much. Using Sierra 22-250 AI data, max of 38.8 gr yielded 3615. Better yet, all bullets made it to the target without issue.
I loaded up a few charges this morning to see how they group. Going to see if I can push them to ~ 3700. Assuming these shoot well, they should be pretty rough on varmints/predators.