My rule of thumb these days is to avoid places that are a "destination." I know something might be a destination when it has a reputation for remoteness, or it's in a designated wilderness area, or it has a romantic sounding name, or at least it has the word "peak" or "lake" in the name.
As some have mentioned, having a day of secluded hunting is often still possible closer in when you learn the little "hidey holes." These usually take some time (seasons) to learn, and they change periodically according to weather, fire, and other factors, so periodically you are relearning them. That can make it difficult for NRs, sometimes almost impossible, unless they have a local friend.
These realities don't lend much to romantic notions, but Lewis and Clark have been gone for a while, so there it is.