Agree with 50. Think about 25 or so if you really want to be precise with close in shots on pests or small critters (head shots on squirrels).
with a 50 yard zero you will have 3-7 inches of bullet drop at 100. If you do a lot of shooting at that range, then you will need to dial or work out a holdover and you will need some very consistent (higher price) ammo.
with a 100 yard zero, you are gonna be 2-3 inches high at 50 yards, which is minute of squirrel / critter adjustment and can cause a miss Or a bad hit at closer range.
again, to keep most 22s grouping well and consistently, you need to feed them good ammo. The Walmart grade cartons of plinking ammo have been very inconsistent for me in the last few years. I haven’t bothered to crono them, but based on sound, groups and gun function it seems like a fairly wide variation in powder charges. for steel challenge, and small bore silhouette matches, I tend to shoot CCI minimags or better Based on what I can find.