I’ve had the ruger sp101 and S&W 340 in 357, S&W 396 in 44 spc, Alaskan and S&W 69 and 329 in 44, SRH in 454, glock models 29 and 40, also S&W 500 in 6.5” and 5” barrels. I keep eyeing something in 480 but the options are limited (wish it was in a redhawk).
After experiencing the above, my favorite is the 329 with x frame grips loaded with 265 grain copper monometal from buffalo bore. It’s got a wide meplat, much better than a semi auto can reliably feed. To get to the next level, I’d go up to a heavier steel frame revolver in 45 colt in the redhawk. There’re powerful loads for 45 colt specifically for the stronger rugers out there that beat the 44 mag. In my opinion, 454 casull doesn’t gain much performance for the recoil and blast penalty. Which is why the 480 has potential if it’s in a revolver that you like. Those who’ve used it, say it hits big animals harder than the 454 with less recoil.
My 5” 500 is a John Ross edition. It weighs 57 oz (similar to the 4” version) so it’s about twice as heavy as the 29 or 329 but not unpackable. It’s a bucket list item of mine to take a moose or bear with it.