The answer is sort of.
Yes, its an angle that changes the horizontal distance, so it does affect your zero. BUT 6-8’ over 300’ (100 yards) isnt enough that most people could possibly notice it. I think most laser rangefinders arent even accurate enough to measure that difference consistently.
At some point angle definitely needs to be taken into account, so yes it DOES make a practical difference at shooting ranges, obviously a bigger difference the steeper the angle and the longer the range. At that point you need horizontal distance for elevation, but you also need line of sight distance for windage. Ideally your RF will provide both line of sight and angle-compensated values, but I know many only provide one value, in which case youre at a real disadvantage imo.
There’s probably a practical rule of thumb about what points (angle and/or range) it needs to be taken into account. Its not something Ive had to deal with much so Im not the guy to provide that.
You might just plug numbers into a ballistic calculator for a couple distances at 5 or 10-degree increments and see what the results are. That’ll tell you how much error it would cause, and allow you to come up with your own distance/angle “triggers”. For my 6.5cm it takes 15 degrees incline to change my hold .1mil at 400 yards, and it goes up from there.
I think I recall one of the THLR videos going over this. Maybe search for that, or perhaps he can weigh in here, Ive found his practical advice to be helpful in the past.
@THLR
This one might help