One and Done EDC handgun - looking for advice

I put carry in two categories.

If you want the most shootable with compact size/conceal-ability the 43 or plain 365 are hard to beat. I do not particularly enjoy shooting either one (snappy)

The 48 or 365 macro are easier for me to shoot and only slightly harder to carry size wise. If you like to mess with stuff go Glock, if you want something out of the box get the sig.

I’d go through a few holsters and find what you like, people often underestimate the right one and a solid belt.
 
You can get slide milled on one of the pistols you have and get optic of your choice put on it.
I second just getting your slide milled for a direct mount with your optic instead of an MOS plate or something like that. You'll get a much better fit.

I carry an M&P 2.0 compact with an Apex trigger in it + TLR-7A. Will be getting the slide milled for an RMR by Jagerwerks sooner than later. I got it over a Glock 19 because I really like how rough the stippling is (I get sweaty hands when I shoot), but I would have no problem running a Glock either. I carry AIWB in a sidecar style holster, so some people may not like how rough the grip is against your skin, but I don't mind it. The stock M&P trigger was awful for me though.

I'd say go with what you shoot best and what will be comfortable enough for you to actually carry. Go to a range where you can rent them and try them out if you don't know anyone that owns one. I personally hate the grip on the Sig, I feel like I can't get my hand high enough into the grip, like the beavertail isn't aggressive enough if that makes sense. And as others have said, a good belt will make a lot of guns comfortable to carry.

I wouldn't worry too much about printing, most of society is too oblivious to their surroundings to notice.
 
Eh. Everything people have already mentioned works. I’m kind of obsessed with carry guns, and I’ve owned pretty much everything listed.

It’s the wizard, not the wand.

They are all mostly the same. Pick one and do what almost no one does: become proficient with it by shooting it, and whatever you choose will work fine.
 
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