I'll be the counter point, I run most of my rifle cans on Xeno. while I still use DT on some hunting cans (mostly non-hub where I don't have the option), I prefer Xeno for most purposes. Being a LH thread taper system, Xeno is about as repeatable as it gets accuracy and POI-wise (regularly use mine out to 1k yds), stays mounted tightly better than DT without having to use anything like Teflon tape, and unlike some of the right-hand taper systems, due to the LH threads, the Xeno mount will never stick to the muzzle device and unscrew from the can body when being removed from the rifle. Also I when swapping cans around, which I do pretty frequently, you're putting wear on relatively large, nitrided, easily replaced threads on the Xeno interface instead of the relatively soft, small and sometimes galling-prone threads on your barrels.
The cost of using Xeno, in my opinion is.... cost, about 5/8" total system length and about 2 oz ( w/Xeno Xero muzzle device) over the same can with DT. Of course, one of the nice things about Hub is you can try either, or something totally different and change your mind later and go a different direction if you want.
The pros and cons are probably going to weight out differently for different people, but that's generally where I've settled