I always shoot yotes, even if it pooches my dusk set. Killing coyotes is something I have never regretted. I name them. Thus far, they were all named Demi.
I never pass up yotes while gun hunting. I've shot them with handgun, turkey shotgun, and deer rifle. Trying complete the Wylie coyote "slam" with the muzzleloader if I get a chance.
Nice lefty muzzleloader you have. I shoot .570 hornady balls with .015 or sometimes .018 patches. I think those are pretty much pure lead and get 50/50 exit wounds using them.