In your opinion what 3-5 rifle cartridges are best for Mule Deer?

A 24” 6.5x284 was my long range muley/elk gun for years with 156 Bergers.

These days I’m running a 21” 6 Creed with 108 Bergers mostly.

Kills seem to be just as quick but it’s a handier platform, allows me to shoot suppressed and still spot impacts, and gives me plenty of juice out to 800 + yards.
 
so far ive managed to kill them with a 300 wsm, a 6.5 prc and a 22 arc. all have been very dead. also killed whitetail and blacktail, with a lot of different cartridges, everything from 357 mag to 338 lap, as well as archery. cant say one outperformed the others. A good bullet, placed where it needs to go, gets a good result.

my personal favorite right now is a 6.5 prc loaded with 156 eols, my 25x7prc comes in at a close second, then probably the 22 arc. Honestly though its a bit like asking a person what their favorite color is.
 
I like speed for my deer rifles. Admittedly haven’t shot any with an eld-m or TMK out of a 22 caliber.
So I pick:
270 wsm
25-06
7mm wsm
6.5 PRC
7mm rem mag

The 150 grain power max bonded (PHP) out of the 300 wsm was as close to a guaranteed instant lights out cartridge that I’ve seen on deer. Only one that took a step was farther than I should’ve been shooting when I was 18, but that deer still only went 40ish yards and died. 50 deer (give or take) only movement was falling with a bullet in the “crease.”
Everything gets shot with a 200 grain ELDx these days though.
 
I’ve used 35 whelen
7mm rem mag
300 win mag
300 prc
6.5 cm
7mm-08
25-06
308
243 win
280AI
340 weatherby
50lb longbow

They all work fine. Pick something you shoot well, match a good bullet to what your rifle likes and practice. Go kill stuff after.
 
I would use my 6 creed, unless I get to the point I could out shoot it in which case I would step up to 6.5 prc.
 
With today's monolithic coppers, really, it's more about finding a rifle in "decent" cartridge for the distances you often encounter them, that doesn't weigh a ton, and then remembering NOT to "Hubble it up" with more glass than you need.
 
The answer to this question likely depends heavily on which part of the last century you were born in.

For the old guard:
7mm Rem Mag/264 Win Mag
.270 Win
.25-06
.308 Win/.30-06
7x57
6.5x55
.257 Roberts
.243 Win/6mm Rem
.220 Swift
.22 rimfire

For the newer generation:
7 PRC
6.5 PRC
6.5 Creedmoor
7mm-08/.260 Rem
6 Creedmoor
25 Creedmoor
22 Creedmoor
.223/5.56

If you notice parallels, you aren’t crazy. Market tastes have come and gone, but the successful recipes haven’t changed.

For me personally it’s been:
.308
7x57
.270 Win
6.5x55

Hoping to add 6-284 to the list next.
 
Ive only killed one muley buck with a rifle and that was a .308. All others were archery or muzzleloader. If I got a rifle tag today I would probably use the 22-250 ai with 88 tmk or 6.5 prc or 280ai.
 
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