This is a good video, but it's still drawing conclusions from groups without applying the variability. I'm not a statistician, so I'm probably messing this up. Maybe @solarshooter can chime in with corrections, but this is where my head goes when I watch this video-As another data point, among many, is this comparison of 3 shot ladder tests to find nodes in a 308 hunting rifle backed up with larger groups that also confirm the same best and worst nodes. One set of tests was 800 rounds ago and it’s duplicated now for comparison. He does a good job of summarizing EC and what the Hornady boys have said, with what is seen in his rifle.
His takeaway is it made about 1/4 MOA difference, which may or may not be worth the time and money to shoot it for someone else.
Hornady says there's still 20-25% variability in 20 shot groups, and 15-20% in 30 shot groups, even 10% still in 50. The way they explain it is that percentage stat is +/- from an average. Since this is a single group and not an average, one would have to consider the possibility that it's on the low end of the expected spectrum, so it could have ~40+% increase (splitting the difference using 20%) if repeated, so ~1.2", very close to the other group.
Factor in shooter ability, weather, fatigue, and 50 rounds out of a bare muzzle 308, and there's just not enough there for me to conclude that one seating depth was actually better than the other.