Just to see what you're working with gun wise, I'd suggest you try a 168 Sierra Match King (SMK), seated to about 2.813 (unless that's to long for your chamber, but I've never seen one that it was).
The 168 SMK is consistently the the most accurate bullet I've ever shot in any gun with a .308 bore (30-06, 308 Win, etc), and it shoots great with just about any amount of jump. Those even shoot sub-MOA in my Howa Super-Lite! I don't think I've ever owned a 308 that shot better with something other than 168 SMK's and Varget in well prepped brass.
For powder, N150 is basically Varget with an ever so slightly slower burn rate. In my 308's, I've always found Varget produces noticably better accuracy with 165/168 class bullets than it does with 150's, and given the burn rate of N150, I'd expect it will be about the same in that regard. I've never had bad luck with any VV powders, so I think that's probably good to go, but Varget is the gold standard baseline for 308/168 SMKs.
Anyway - I recommend you try your N150 and 168 SMK's and see what you get. I bet you get some very good accuracy, and then you will have your baseline for how well (or not) other loads shoot in that gun.
The "Easy Load Development" thread is pretty spot on in concept - any given bullet + powder + primer + brass + your loading technique, is probably gonna shoot about how it shoots in your gun. Different combo's can shoot WILDLY different in any given gun also.
Also, I'll re-echo what others are saying - 5 round groups can only tell you if any given load is bad; it's not enough to tell you if it's really good. If you shoot a 5 round group (or even a 3 round group) and think "wow, that sucks", there's basically a 0% chance that group is going to turn around and make you happy if you keep sending rounds. If you shoot a 5 round group that looks nice, all that proves is that those 5 rounds landed close together; you'd need to see a minimum of another 10 before you should get too excited, and another 25 before you start feeling confident about what your+your gun+your loads is capable of. Don't get disapointed if it turns 1.5-2 MOA is all you get - that's all 99% of the hunting-gun class guns is capable of when the round count on group size goes up.
Seating depth is chasing your tail - I have seen guns shoot somewhat better and somewhat worse with seating depth, but you won't turn 3MOA into 1MOA with seating depth, but you might turn 2MOA into 1.75MOA or somesuch.
Powder selection matters a LOT more than I think many people give it credit for. For 150's in a 308 Win, you're probably going to find that powders a bit faster than N150 produce the best groups. Things like H4985, N140, maybe even as fast as H322 or AR-Comp or N13x. My 'money' load back when I ran 150's in a 308 was h4985, and I had experimented briefl with AR-Comp with even better results, but then AR-Comp got hard to come by and I've since moved to 165/168's in all my 308s.
Here's a good example of how much powder selection can matter:
This is 10 rounds of 7x57 Mauser, 162 ELD-X, @ 3.210 OAL, H4350 loaded at 2664 FPS. Not awful, but not impressive either; I'm confident a 30 round group of this would come in arond 2-2.25 MOA.
And this, is also 10 round sof 7x57 Mauser, 162 ELD-X, @ 3.210 OAL, N555, loaded to 2667 FPS, out of the same gun, shot I think 2 days apart. I've drilled 30 rounds of this load into a 1.1 MOA group before. The one and only variable here, is I switched from N555 to H4350.
Anyway, hope all this helps.