7 PRC. 28 nosler if one thinks they need to go crazy fast. Other than current factory ammo options, i don't see a single upside to a 7RM over a PRC.
On a custom barrel, the only thing a 6.5-300 weatherby has going for it over a 26 nosler is some people think the weatherby name is cool. Any performance improvements the weatherby has over the nosler is due to a longer throat or more pressure, neither of which matter on an aftermarket barrel where the throat can be spec'd and which will be handloaded for. But with the weatherby you'd get the luxury of paying more for lesser brass that comes with a belt. Still, I think frank green of bartlein summed em up well with how the 26 nosler was referred to as 26 why and 26 stupid in industry circles.