I'm a big fan of a Kydex holster mounted to the bottom of my Marsupial bino pouch. That way if I want to drop/add a warming layer, I don't have 2 sets of straps to undo. I can drop my pack and still have my pistol on me, and it's too easy to put on.
For non hunting activities like fishing and hiking, I have a Hill People Gear kit bag that can carry a full sized pistol and doesn't scream "gun."