It doesn’t matter, until it does. The biggest difference I’ve personally seen was 50 fps, which is significant. I don’t worry about it and simply do a quick check on a few rounds. Crap lots, either velocity or accuracy, simply get used for plinking/training rounds and I’ll never mix.
Every year someone has a weird lot and everyone convinces them to mix it with another good lot and all it does is create two bad lots, that is still significantly different from a normal one. The worst was a guy who had terrible accuracy with a new 8lb jug, so he was convinced to buy a second 8 lb jug and mix them - the rifle shot like crap with the mixed lot. I suggested buying a single pound, don’t mix it, and if accuracy came back the problem was the first powder. The problem was that first bag jug, but he now has $800 of crap powder sitting on a shelf.