I have read that a full case will produce a more consistent load. Has something to do with the powder settling in the case after it is chambered and when getting ready to fire it. I have also heard that loads with lower volumes could be dangerous due to the powder possibly bunched up at the bullet, and air space near the primer, the primer flash hits across the top of the entire powder charge, and not a progressive burn as a full load would produce. If you are looking for a reduced load, make sure you don't reduce the powder charge less than recommended minimum published loads.
If you are trying to load light loads for reducing recoil purposes, consider going to a lighter bullet and using a recommended starting load. Generally a lighter bullet will produce less recoil than heavier bullets. Also, a slip on recoil pad works wonders in reducing the felt recoil.