Can you realistically fight off a 100+lb dog or are you going to lose?

[left field]

Those CAOs are next level!

Yeah. Power, speed, and a strong defensive drive. Need to be trained to bite well though.

This is another thing to consider. The vast majority of dogs will bite with the front teeth and pull back. If you can get them to take clothes, you could hold them off for a while.

Protection and sport dogs are trained to dig in and bite with the back of their jaws. This does a couple of things. It is the most powerful bite placement a dog has, and it ensures that the bite is hard to shake.

Consider a nutcracker. You don't use the tips of the arms to crack a nut, you put it in the fulcrum or hinge. People often talk about how powerful the bite of a molosser or bull breed it. Yes, they strong but a well bred GSD is the strongest bite I've ever felt, in part because the longer jaws allow for more leverage (effort) applied to the hinge.

Training a dog to bite deeply meant posting him up and feeding him your leg until the bite went in. Pulling back and then releasing to drive him in even more. I would come home purple from my knees to my hips.