Have you got your powder charge figured out already? Best to get that squared away before playing with depth IMO.
+1 on that.
If your mag box won't allow you to seat the bullet near the lands and the bullet is 80-100 thousanths or more off the lands, then varying the seating depth is not going to make as much of a difference on group size as varying the powder and charge weight.
Or even the bullet.
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