This is just my opinion....and my sample sets are 1 and maybe 300. I lived in the deserts of New Mexico for about 10 years. Loved it. Channeled my inner Elmer Keith/Brain Pearce often. Spent a ton of time and money on handguns....and hard cast. I probably shot 300+ jackrabbits with 250K in a 44mag, but mostly 315 LFN out of some flavor of 45LC. I don't recall dumping too many on the spot and more often than not, I'd almost swear I could see daylight thru the .452" hole punched through them. Shot a coyote with a cast bullet on the lope....never did recover him after what I thought was a decent blood trail through the greasewood. Synopsis....not at all impressed.
Fast forward through some 454 Casull, 475 Linebaugh BFRs, and Super Blackhawk Hunters (before they were reintroduced and I got soaked for paying what I did). I took a treed black bear a few years ago. Spot and Stalk and it winded and treed while I was stalking. Didn't weigh it. Decent. Several years old, but eastern WA bears are much different than NJ bird feeder bears. Fall bear....225-250lb boar. Used a 480 Ruger Super Redhawk. Various angles and it was thick. Bear ate a full cylinder. These were 385 grain WFNs. I felt like shit. Never again. I've sworn off HC.
Bassman lives in legit grizzly country. I own a cabin/property in legit grizzly country. So this in not Midwestern "Wishful Thinking" and day dreaming of a "Bear Load" should I ever go Out West.
I'm quite confident an XTP or Gold Dot will penetrate adequately from a 10mm. A Lehigh more so. Forums have gone round and round for pages of people "parroting" the same stuff. BB, DT, or Under 200 or 220 HC.
As Crowder says: " I think pushing a dinky .401" HC hole through a bear is far from the best bullet when many other jacketed, controlled expansion bullets are readily available.....Change my Mind"